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roman chamomile extract
- Development stage
- Unknown
- Lead developer
- Sibelius Natural Products
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Roman chamomile extract (Sibelius™: Chamomile) is a proprietary botanical natural product developed by Sibelius Limited. Derived from a specific non-GMO cultivar of *Chamaemelum nobile*, the extract is standardized for active components including flavonoids and azulene compounds. It was developed using the Chronoscreen™ platform, which utilizes *C. elegans* to identify biological activity and evaluate biological effects. The extract exhibits anti-inflammatory, antioxidant, and immune-modulating properties, specifically targeting vascular inflammation pathways. While traditionally used as a nutraceutical for sleep support and relaxation, it is currently being investigated as a potential therapeutic for Long COVID, with clinical research focusing on its ability to modulate systemic inflammatory marker release.
- Brand names
- Sibelius: Chamomile
- Other names
- Chamaemelum nobile extract
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)VEGFR2 (Vascular endothelial growth factor receptor 2)BZD site (GABA-A receptor benzodiazepine site)IKK complex
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