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roniciclib
- Development stage
- Phase 2
- Lead developer
- Bayer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Roniciclib is an orally bioavailable small molecule inhibitor of cyclin-dependent kinases (CDKs) with potential antineoplastic activity. It selectively binds to and inhibits the activity of several CDK subtypes, including CDK1/Cyclin B, CDK2/Cyclin E, CDK3, CDK4/Cyclin D1, CDK5, CDK6/Cyclin D3, CDK7, and CDK9/Cyclin T1. These serine/threonine kinases are essential for cell cycle progression and cellular proliferation. Inhibition by roniciclib leads to cell cycle arrest during the G1/S transition and induces apoptosis in tumor cells. Roniciclib has been investigated primarily for the treatment of small cell lung carcinoma and other solid tumors but its development was terminated after phase II due to safety concerns[2][3][4][5][6][7].
- Other names
- roniciclib
02
Targets
AURKA (Aurora kinase A)CDK3 (Cyclin-dependent kinase 3)CDK7CDK1 (Cyclin-dependent kinase 1)CDK4 (Cyclin-dependent kinase 4)CDK2 (Cyclin-dependent kinase 2)CDK9 (Cyclin-dependent kinase 9)
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