ropivacaine + bupivacaine + fentanyl

This drug entry refers to a specific epidural analgesic regimen evaluated by the **University Hospital, Basel**, for postoperative pain management in patients undergoing elective laparoscopic colorectal resections. The regimen involves the epidural administration of either **ropivacaine** (marketed as Naropin) or **bupivacaine** (marketed as Duracain) in combination with the synthetic opioid **fentanyl**. Ropivacaine and bupivacaine are aminoamide-type local anesthetics that function by inhibiting voltage-gated sodium channels, thereby blocking the conduction of nerve impulses. Fentanyl acts as a potent agonist at the mu-opioid receptor to provide regional and systemic analgesia. This combination is delivered via an epidural catheter to provide superior pain control and potentially accelerate the resolution of postoperative ileus compared to traditional systemic opioid-based analgesia.

Brand names

NaropinDuracain

Other names

epidural analgesia (Duracain/Fentanyl/Naropin)epidural analgesia-University Hospital, Basel, Switzerland-pain