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ropivacaine + morphine + epinephrine + ketorolac
- Development stage
- Phase 4
- Lead developer
- QuVa Pharma
- Modality
- Small Molecules
- Administration
- Intraarticular, Periarticular
01
Overview
A multimodal analgesic combination used for periarticular and intraarticular pain management, particularly following orthopedic surgeries. This combination provides synergistic pain relief through multiple mechanisms: - Ropivacaine: A local anesthetic that inhibits afferent pain signals - Morphine: An opioid that provides analgesia through central and peripheral opioid receptors - Epinephrine: A vasoconstrictor that prolongs the local effect of the other drugs - Ketorolac: A non-steroidal anti-inflammatory drug that decreases the release of inflammatory mediators The combination is typically administered via intraarticular or periarticular injection during surgery, with some protocols including additional postoperative injections through catheters.
- Other names
- periarticular multimodal drug injectionintraarticular regional analgesiahigh-volume local infiltration analgesia
02
Targets
AR (Adrenergic receptors)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)KCNA5 (Ultra-rapid delayed rectifier potassium channel)MOR (Mu opioid receptor)NaV (Voltage-gated sodium channels)
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