Drug intelligence / Profile preview

ropivacaine or levobupivacaine

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Epidural, Intrathecal, Perineural, Infiltration
01

Overview

This term is **non-specific**: it denotes an alternative choice between **ropivacaine** and **levobupivacaine**, two distinct long-acting amino-amide local anesthetic drugs, rather than a single molecular entity or a co-formulated combination. Both reversibly inhibit voltage-gated sodium channels in peripheral nerves, preventing action-potential initiation and propagation to produce regional anesthesia and analgesia. In the provided rotator-cuff-repair study, either agent may be used for loco-regional anesthesia. Ropivacaine injection is indicated for local or regional anesthesia and acute pain management. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=da1ce22b-6a8e-40a2-afbb-011fa3ed3a8b))

02

Targets

KCNH2 (Voltage-gated potassium channel subfamily H member 2)SCN5A (Sodium channel protein type 5 subunit alpha)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)

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