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ROS-ERS inducer 1
- Development stage
- Preclinical
- Lead developer
- Nanjing University of Chinese Medicine
- Modality
- DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules
01
Overview
ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. It functions as a type II immunogenic cell death (ICD) inducer by triggering endoplasmic reticulum stress (ERS) and generating reactive oxygen species (ROS), which together lead to the release of damage-associated molecular patterns (DAMPs). This mechanism promotes immunogenic cell death in cancer cells, particularly hepatocellular carcinoma and multiple myeloma, resulting in enhanced antitumor immunity through dendritic cell maturation and T-cell activation. Preclinical studies show that ROS-ERS inducer 1 exhibits significantly higher anticancer activity than cisplatin[1][2][3][4][5][7].
- Other names
- REI
02
Targets
TXNRD2 (Thioredoxin reductase 2)
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