Drug intelligence / Profile preview

rose hip seed oil

Development stage
Unknown
Lead developer
Trilogy Natural Products
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

Rose hip seed oil is a lipid-rich extract obtained from the seeds of wild rose bushes, primarily *Rosa canina*, *Rosa rubiginosa*, or *Rosa moschata*. It is characterized by a high content of essential fatty acids, specifically linoleic acid (C18:2 n-6) and alpha-linolenic acid (C18:3 n-3), which are critical for maintaining the integrity of the skin's stratum corneum and barrier function. The oil also contains significant levels of all-trans retinoic acid (tretinoin), tocopherols, and carotenoids, which contribute to its regenerative and antioxidant properties. Its mechanism of action involves the inhibition of pro-inflammatory enzymes such as cyclooxygenase (COX-1 and COX-2) and lipoxygenase, as well as the modulation of cytokine production. Clinically, it is utilized topically to improve the appearance of scars, striae, and photoaging, and is occasionally used as a dietary supplement to support joint health and systemic anti-inflammatory responses.

Brand names
The Ordinary 100% Organic Cold-Pressed Rose Hip Seed OilTrilogy Certified Organic Rosehip OilPai Skincare Rosehip BioRegenerate OilSukin Certified Organic Rosehip Oil
Other names
Rosa canina seed oilRosa rubiginosa seed oilRosa moschata seed oilrosehip oilRosa mosqueta oil
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)ALOX5 (Arachidonate 5-lipoxygenase)RAR (Retinoic acid receptor)

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