Drug intelligence / Profile preview

rosemary oil

Development stage
Phase 4
Modality
Small Molecules
Administration
Topical, Oral, Inhalation
01

Overview

Rosemary oil is an essential oil derived from the leaves and flowering tops of the *Rosmarinus officinalis* plant. It contains active compounds such as rosmarinic acid, carnosic acid, carnosol, ursolic acid, and betulinic acid that contribute to its pharmacological effects[5]. Rosemary oil exhibits anti-inflammatory activity primarily through inhibition of nuclear factor kappa B transcription and suppression of the arachidonic acid cascade[2]. Its antioxidant properties help prevent injury caused by reactive species during inflammation. The spasmolytic effect on gastrointestinal smooth muscle is attributed to antagonism of acetylcholine (with borneol as a key component), while alpha- and beta-pinenes show spasmogenic activity toward smooth muscle[2][8]. Rosemary oil has been studied for a variety of uses including anti-inflammatory, antimicrobial (antibacterial/antifungal/antiviral), neuroprotective (memory enhancement), analgesic (pain relief), antidepressant-like effects via modulation of noradrenergic, dopaminergic and serotonergic systems in animal models[5], hair regrowth stimulation in alopecia areata[8], improvement in circulation when applied topically[3], menstrual flow stimulation[8], treatment for dyspepsia and hypertension (approved by German Commission E)[4], rheumatism relief[4][3], bronchial asthma support via 1,8-cineole content in small studies[2][4] and other traditional indications such as peptic ulcer or liver toxicity. Ingestion of large amounts can be toxic; topical use may cause skin irritation.

Brand names
Old Man
Other names
Rosmarinus officinaliscompass plantcompass weedpolar plantRosmarinus officinalis Linn
02

Targets

AChR (Acetylcholine receptor)DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)ADRA1A (α1A)NF-κBHTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR3A (5-hydroxytryptamine receptor 3A)

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