Drug intelligence / Profile preview

rosiglitazone + peginterferon alfa-2a + ribavirin

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Oral, Subcutaneous
01

Overview

This is a potential combination therapy consisting of rosiglitazone, peginterferon alfa-2a, and ribavirin. Based on the provided search results, information specifically regarding this *triple* combination for therapeutic use, particularly for hepatitis C virus (HCV) infection, is not available. The search results primarily discuss the *double* combination of peginterferon alfa-2a and ribavirin, which is a well-established treatment for chronic HCV infection. Peginterferon alfa-2a is a modified interferon that, when combined with ribavirin, has shown significantly higher sustained virologic response rates for HCV compared to older regimens. Rosiglitazone is typically used as an antidiabetic medication (a thiazolidinedione) to improve insulin sensitivity; its role in combination with peginterferon and ribavirin for HCV or any other indication is not described in the provided information.

02

Targets

IFNAR (Immune system modulation via type I interferon receptor)PPARG (Peroxisome proliferator-activated receptor gamma)NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)

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