Drug intelligence / Profile preview

rosuvastatin + ezetimibe + acetylsalicylic acid

Development stage
Preclinical
Lead developer
Midas Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Rosuvastatin + ezetimibe + acetylsalicylic acid is a triple fixed-dose combination (FDC) small molecule therapy developed by Midas Pharma for the treatment of dyslipidemia. The product combines three established agents: rosuvastatin, an HMG-CoA reductase inhibitor that lowers LDL cholesterol by inhibiting hepatic cholesterol synthesis; ezetimibe, which inhibits the NPC1L1 transporter to reduce intestinal cholesterol absorption; and acetylsalicylic acid (aspirin), which provides antiplatelet effects via cyclooxygenase inhibition. This combination is designed as a substitution therapy to improve patient adherence and reduce pill burden in individuals already receiving these components as separate or dual-combination treatments. It is available in multiple dose strengths to allow for tailored lipid management and cardiovascular risk reduction.

Other names
rosuvastatin + ezetimibe + ASArosuvastatin + ezetimibe + aspirin
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)PGHS-1 (Prostaglandin G/H Synthase 1)NPC1L1 (Niemann-pick C1-Like 1 transporter)

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