Drug intelligence / Profile preview

rotarix + dpt-hepb-hib + opv

Development stage
Unknown
Lead developer
GSK
Modality
Recombinant Proteins and Enzymes, Live Biotherapeutic Products → Microbiome Therapeutics, Vaccines & Immunotherapeutics
Administration
Oral, Intramuscular
01

Overview

This is a combination immunization regimen consisting of three vaccines commonly administered together in infant immunization schedules: - **Rotarix** is a live attenuated oral vaccine derived from the human 89-12 strain (G1P[8]) of rotavirus. It induces immunity by replicating in the small intestine and stimulating an immune response to protect against severe gastroenteritis caused by multiple serotypes of rotavirus. The precise mechanism of protection is not fully understood but involves mucosal and systemic immune responses[6][8]. - **DPT-HepB-Hib** (also known as the 6-in-1 or pentavalent/hexavalent vaccine) is an injectable combination vaccine that protects against diphtheria, tetanus, pertussis (whooping cough), hepatitis B virus infection, and invasive disease caused by Haemophilus influenzae type b. It works by inducing specific antibody responses to each component antigen[3][4]. - **OPV** (oral polio vaccine) contains live attenuated poliovirus strains that replicate in the gut and induce both humoral and mucosal immunity against poliomyelitis. These vaccines are co-administered to provide broad protection against several serious childhood diseases.

Brand names
Rotarix
Other names
diphtheria-tetanus-pertussis-hepatitis b-haemophilus influenzae type b vaccineoral polio vaccine
02

Targets

FHA (Filamentous hemagglutinin)PRN (Pertactin)VP7 (Rotavirus VP7)HBsAg (Hepatitis B surface antigen)Diphtheria toxinPoliovirus capsid proteinsVP4 (Rotavirus VP4)PRNP (Cellular Prion Protein)

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