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Drug intelligence / Profile preview
rotavirus vaccine, live, oral, pentavalent + diphtheria-tetanus-pertussis (whole cell)-hepatitis B vaccine
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Oral, Intramuscular
01
Overview
RotaTeq + Tritanrix HepB refers to the co-administration of two distinct pediatric vaccines. RotaTeq, developed by Merck, is a pentavalent live oral vaccine containing five human-bovine reassortant rotaviruses (G1, G2, G3, G4, and P1[8]) indicated for the prevention of rotavirus gastroenteritis. Tritanrix HepB, developed by GSK, is a combination vaccine containing diphtheria and tetanus toxoids, inactivated whole-cell Bordetella pertussis, and recombinant hepatitis B surface antigen (HBsAg). This combination is typically administered during routine infant immunization schedules (e.g., at 2, 4, and 6 months of age) to provide broad protection against multiple infectious diseases while minimizing the number of healthcare visits. Clinical trials have demonstrated that the co-administration of these vaccines is generally well-tolerated and does not significantly interfere with the immune response to the individual components.
- Other names
- DTPw-HBDTP-HepBPentavalent rotavirus vaccineDiphtheria-tetanus-whole cell pertussis-hepatitis B vaccine
02
Targets
HBsAg (Hepatitis B surface antigen)VP4 (Rotavirus VP4)VP7 (Rotavirus VP7)TT (Tetanus toxoid)GII.17 VP1 (Norovirus GII.17 VP1)VP4 (Rotavirus outer capsid protein VP4)
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