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Rougan Huoxue Formula

Development stage: Preclinical
Lead developer: East China University of Science and Technology
Administration: Oral

Overview

Rougan Huoxue Formula (柔肝活血方) is a Traditional Chinese Medicine (TCM) herbal preparation primarily used for conditions involving liver dysfunction, such as chronic hepatitis B, hepatic fibrosis, and non-alcoholic steatohepatitis (NASH). Its therapeutic principles revolve around "softening/soothing the liver" (柔肝) and "activating blood circulation" (活血), aiming to nourish liver yin and blood, relieve pain, clear heat, and detoxify. Research indicates its potential to suppress the activation of hepatic stellate cells by downregulating the TGF-β1/Smads signaling pathway, and to attenuate NASH by enhancing fecal bile acid excretion. The formula typically comprises a combination of various herbs, each contributing to its overall therapeutic effect.

Other names: 柔肝活血方柔肝活血汤Rougan Formula

Targets

IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)TLR4 (Toll-like receptor 4)

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