Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ROV protocol pharmacological probes
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
The ROV (Rapid Onset Vasodilator) protocol refers to a specific combination of pharmacological probes used in clinical research by the University of Wisconsin, Madison, to investigate microvascular function and peripheral vasodilation in obese individuals. The protocol utilizes a multi-component approach to dissect vasodilatory mechanisms, specifically targeting potassium-mediated pathways, nitric oxide bioavailability, and prostaglandin signaling. The primary components include barium chloride (a KIR channel blocker), L-NMMA (a nitric oxide synthase inhibitor), ketorolac (a cyclooxygenase inhibitor), and adenosine triphosphate (ATP). This experimental setup is designed to evaluate how obesity alters endothelial-dependent and functional vasodilation in skeletal muscle.
- Other names
- Rapid Onset Vasodilator protocolPeripheral Vasodilation in Obese Humans probes
02
Targets
Kir (Inwardly-rectifying potassium channel)NeuraminidaseNOS1 (nNOS)COX
Beyond the preview
Go deeper on ROV protocol pharmacological probes.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ROV protocol pharmacological probes.