RPL13 siRNA

RPL13 siRNA is a small interfering RNA (siRNA) designed to silence the expression of the ribosomal protein L13 (RPL13), a component of the 60S large ribosomal subunit. Preclinical research, notably presented at the AACR 2013 meeting by investigators from the Penn State College of Medicine, has demonstrated that knockdown of RPL13 inhibits melanoma growth through two primary mechanisms: the disruption of protein synthesis and the activation of the RP-MDM2-p53 tumor suppressor pathway. Depletion of RPL13 leads to the accumulation of free ribosomal proteins, such as RPL5 and RPL11, which bind to MDM2 and prevent the degradation of p53, thereby inducing p53-mediated cell cycle arrest. In animal models, RPL13 siRNA treatment has been shown to decrease tumor growth by 50-90%, suggesting that targeting ribosomal proteins may serve as a novel therapeutic strategy for cancers heavily dependent on protein synthesis.

Other names

siRNA targeting RPL13RPL13-siRNARPL-13-siRNARPL 13-siRNA