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RPTR-1-004

Development stage: Preclinical
Lead developer: Repertoire Immune Medicines
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
Administration: Intravenous

Overview

RPTR-1-004 is an investigational T-cell receptor (TCR) bispecific biologic being developed by Repertoire Immune Medicines in partnership with Pfizer for the treatment of prostate cancer, specifically metastatic prostate cancer. Discovered using Repertoire's proprietary DECODE platform, which maps the immune synapse to identify rare, tumor-selective TCR-epitope pairs, RPTR-1-004 is designed to redirect and activate polyclonal T cells to target and eliminate prostate cancer cells. The candidate is currently in the discovery stage of development.

Targets

CD3 (T-cell surface glycoprotein CD3)pMHC (Peptide-MHC complex family)

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