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RQ-01 is a recombinant polypeptide fusion inhibitor developed for intranasal administration as a treatment for mild COVID-19. It is designed to inhibit the fusion of SARS-CoV-2 with host cells, thereby reducing viral entry and replication. In Phase 1 clinical studies, RQ-01 was administered via nasal spray to adults with mild symptoms of COVID-19 who were at low risk for disease progression. The drug demonstrated safety and tolerability, with a trend toward faster clearance of SARS-CoV-2 infection compared to placebo. Its mechanism involves direct antiviral activity at the site of initial infection in the upper respiratory tract[1][3][2].
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