Drug intelligence / Profile preview

RQ-03

Development stage
Preclinical
Lead developer
Red Queen Therapeutics
Modality
Stapled Peptides → Modified Peptides → Peptides, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
Administration
Intranasal, Inhalation
01

Overview

RQ-03 is a pan-influenza therapeutic candidate developed by Red Queen Therapeutics using its proprietary stapled lipopeptide platform. The drug functions by inhibiting viral fusion proteins, a critical and highly conserved step in the viral life cycle, thereby preventing the influenza virus from entering host cells. This mechanism of action is intended to provide broad-spectrum protection against a wide range of influenza strains and variants. Currently in the discovery and preclinical stages, RQ-03 is slated to begin IND-enabling studies in early 2025. The program's development is supported in part by a contract from the Biomedical Advanced Research and Development Authority (BARDA), highlighting its potential role in pandemic preparedness and seasonal flu management.

02

Targets

HA0 (Influenza B virus hemagglutinin)

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