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RS-001
- Development stage
- Phase 1
- Lead developer
- Guangdong Ruishun Biotechnology
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
RS-001 is a CAR-T cell therapy targeting CD19 and expressing membrane-bound interleukin-15 (mbIL15) on double-negative T cells (DNTs). It is being developed for the treatment of B-cell malignancies, including high grade B-cell lymphoma, mediastinal large B-cell lymphoma, and Philadelphia positive acute lymphocytic leukaemia. The therapy aims to enhance anti-tumor activity by combining the specificity of CD19-targeted CAR-T cells with the proliferative and survival benefits conferred by mbIL15 expression. Multiple companies are developing similar or related products under the name RS-001[3][4][5].
- Other names
- RS-001(Ruishun Biotech)RS 001 (WYZE Biotech)
02
Targets
IL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)CD19 (B lymphocyte antigen CD19)
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