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RST-201

Development stage: Preclinical
Lead developer: ReST Therapeutics
Modality: Small Molecules

Overview

RST-201 is a small molecule NMDA receptor (NMDAR) modulator specifically targeting the GluN2D subunit, currently in the discovery and preclinical stages of development by ReST Therapeutics for the treatment of Alzheimer's Disease. ReST Therapeutics' platform focuses on "Precision Neuropsychiatry" by addressing NMDAR overactivation, which is implicated in various neuropsychiatric and neurodegenerative disorders. By selectively targeting the GluN2D subunit, RST-201 aims to provide neuroprotection and restore cognitive function while minimizing the side effects typically associated with broad-spectrum NMDAR antagonists.

Targets

GRIN2D (Glutamate receptor ionotropic NMDA subunit 2D)

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