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RSV alphavaccine

Development stage
Preclinical
Lead developer
AlphaVax
Modality
Viral Vectors → Gene Addition/Replacement → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

RSV alphavaccine is an investigational vaccine candidate developed by AlphaVax for the prevention of respiratory syncytial virus (RSV) infection. It utilizes a proprietary alphavirus replicon particle (VRP) technology derived from the Venezuelan Equine Encephalitis (VEE) virus. These VRPs are engineered to be replication-defective and serve as a delivery vehicle for RNA encoding RSV-specific antigens. By targeting dendritic cells in vivo, the vaccine induces high levels of antigen expression, triggering both potent T-cell mediated immunity and neutralizing antibody responses against the virus. The platform is designed to provide a robust immune response without the risk of viral propagation or disease associated with live-attenuated vaccines.

Other names
RSV VRP vaccineRSV RNA particle vaccineAlphaVax RSV vaccine
02

Targets

RSV G (Respiratory syncytial virus attachment glycoprotein)

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