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RT-I53-50
- Development stage
- Preclinical
- Lead developer
- University of Washington
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
RT-I53-50 is a computationally designed, self-assembling protein subunit nanoparticle vaccine candidate developed for the prevention of malaria. It is built on the two-component icosahedral I53-50 nanoparticle platform, which consists of 60 trimeric (I53-50A) and 60 pentameric (I53-50B) subunits. RT-I53-50 displays 60 copies of the "RT" antigen, which is the antigenic portion of the RTS,S malaria vaccine derived from the *Plasmodium falciparum* circumsporozoite protein (PfCSP). This antigen contains 19 repeats of the "NANP" amino acid sequence (repeat region) and the C-terminal domain (CTD) of PfCSP. The vaccine is designed to elicit potent humoral and cellular immune responses, particularly targeting the liver-stage of malaria infection, and has shown comparable efficacy to the R21 vaccine in preclinical models.
- Other names
- RT-I53-50 nanoparticleRT-I-53-50 nanoparticleRT-I 53-50 nanoparticleRT.2-I53-50
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