RU 58668

RU 58668 is a synthetic steroidal pure antiestrogen that acts as an estrogen receptor antagonist with no measurable agonist activity. It binds to estrogen receptors with high affinity and blocks estrogen-dependent signaling. RU 58668 exhibits potent antiproliferative effects in vitro in estrogen receptor-positive breast cancer cell lines, such as MCF-7, with IC50 values in the sub-nanomolar range. In vivo, it downregulates estrogen receptor expression and induces long-term regression of human mammary carcinoma xenografts, including tamoxifen-resistant tumors, in animal models. It was developed primarily for research on hormone-dependent cancers, especially breast cancer[1][3][5][8].

Other names

151555-47-4Estra-1,3,5(10)-triene-3,17-diol, 11-[4-[[5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl]oxy]phenyl]-, (11beta,17beta)-11beta-(4-(5-((4,4,5,5,5-pentafluoropentyl)sulfonyl)pentyloxy)phenyl)-estra-1,3,5(10)-triene,3,17beta-diol