Drug intelligence / Profile preview

rubidium-82 chloride

Development stage
Approved
Lead developer
Bracco Diagnostics
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Rubidium-82 chloride is a **radiopharmaceutical diagnostic agent** primarily used in **Positron Emission Tomography (PET) imaging** of the myocardium, under rest or pharmacologic stress, to evaluate **regional myocardial perfusion** in adult patients with suspected or known **coronary artery disease**[1][2][3][5]. The compound consists of the radioactive isotope rubidium-82 (half-life 75 seconds), produced onsite from a strontium-82 generator and administered intravenously. Biologically, Rb-82 acts as a **potassium analog** due to its similar ionic radius, allowing it to be rapidly taken up by myocardial cells in proportion to blood flow, thus enabling perfusion imaging[2][4]. In areas of infarction or ischemia, reduced uptake provides diagnostic information about myocardial viability[1][2].

Brand names
CardioGen-82CardioGen82CardioGen 82Ruby-Fill
Other names
rubidium-82 chloriderubidium82 chloriderubidium 82 chloriderubidium Rb 82 chloride injectionRb-82 chlorideRb82 chlorideRb 82 chloriderubidium-82rubidium82rubidium 82rubidium chloride Rb-82
02

Targets

ATP1A (Sodium/potassium-transporting ATPase)

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