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*Rumex acetosa* extract, derived from the leaves and stems of the common sorrel plant, is a botanical substance primarily utilized for its secretolytic, anti-inflammatory, and antimicrobial properties. It is a significant component of standardized phytotherapeutic preparations used to treat respiratory conditions, such as acute and chronic rhinosinusitis. The extract exerts its therapeutic effects by stimulating chloride secretion in the respiratory epithelium, which reduces mucus viscosity and facilitates mucociliary clearance. Additionally, it contains active phytochemicals including flavonoids (such as hyperoside and quercitrin), tannins, and anthraquinones that inhibit the production of pro-inflammatory mediators like cyclooxygenase-2 (COX-2) and prostaglandin E2. While often used in combination with other herbs, the extract itself is recognized for its ability to modulate the inflammatory response and support the drainage of the paranasal sinuses.
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