Drug intelligence / Profile preview

rumex obtusifolius extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

*Rumex obtusifolius* extract is a botanical preparation derived from the broad-leaved dock, a perennial herb widely distributed in temperate regions. The extract is rich in secondary metabolites, including anthraquinones (such as emodin, chrysophanol, and physcion), tannins, and flavonoids. Historically used in traditional medicine for its laxative and skin-healing properties, modern pharmacological research highlights its potent antimicrobial activity against various pathogens, including *Staphylococcus aureus* and *Escherichia coli*. Its mechanism of action involves the disruption of microbial cell membranes and the inhibition of key signaling enzymes like Casein kinase II (CK2). Furthermore, the extract exhibits significant antioxidant and anti-inflammatory effects by scavenging reactive oxygen species and suppressing the NF-kappaB pathway. It is primarily utilized as a dietary supplement or topical herbal remedy.

Other names
Broad-leaved dock extractBitter dock extractRumex obtusifolius L. extract
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)AKT (RAC-alpha serine/threonine-protein kinase)TNFA (Tumor necrosis factor alpha (soluble))PI3K (Phosphoinositide-3-kinase regulatory subunit 6)MMP2 (Matrix metalloproteinase-2)

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