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Drug intelligence / Profile preview
rumex obtusifolius extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral, Topical
01
Overview
*Rumex obtusifolius* extract is a botanical preparation derived from the broad-leaved dock, a perennial herb widely distributed in temperate regions. The extract is rich in secondary metabolites, including anthraquinones (such as emodin, chrysophanol, and physcion), tannins, and flavonoids. Historically used in traditional medicine for its laxative and skin-healing properties, modern pharmacological research highlights its potent antimicrobial activity against various pathogens, including *Staphylococcus aureus* and *Escherichia coli*. Its mechanism of action involves the disruption of microbial cell membranes and the inhibition of key signaling enzymes like Casein kinase II (CK2). Furthermore, the extract exhibits significant antioxidant and anti-inflammatory effects by scavenging reactive oxygen species and suppressing the NF-kappaB pathway. It is primarily utilized as a dietary supplement or topical herbal remedy.
- Other names
- Broad-leaved dock extractBitter dock extractRumex obtusifolius L. extract
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MMP2 (Matrix metalloproteinase-2)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)TNFA (Tumor necrosis factor alpha (soluble))CK2 (Casein kinase II subunit alpha)NF-κB
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