Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
RUNX1 mRNA
- Development stage
- Preclinical
- Lead developer
- NANO mRNA
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intraarticular
01
Overview
RUNX1 mRNA is a preclinical mRNA-based therapeutic being developed by NANO mRNA (now Nano Holdings, Inc.) for the treatment of knee osteoarthritis. The drug utilizes a polyplex nanomicelle delivery system composed of polyethylene glycol (PEG)-polyamino acid block copolymers to deliver mRNA encoding the transcription factor RUNX1 (runt-related transcription factor 1) directly to articular cartilage. By restoring or augmenting RUNX1 expression, the therapy aims to promote chondrocyte proliferation, enhance cartilage-anabolic markers, and suppress the progression of osteoarthritis, potentially providing both structural repair and pain reduction.
- Other names
- NANO mRNA-RUNX1-mRNA-Osteoarthritis (knee)RUNX1 mRNA therapeuticRUNX-1 mRNA therapeuticRUNX 1 mRNA therapeutic
02
Targets
RUNX1
Beyond the preview
Go deeper on RUNX1 mRNA.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on RUNX1 mRNA.