Drug intelligence / Profile preview

ruta chalepensis acetone extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Ruta chalepensis acetone extract is a phytochemical preparation derived from the fringed rue plant (*Ruta chalepensis*), a medicinal herb traditionally used for cardiovascular and other ailments. Phytochemical profiling indicates that the acetone extract is primarily composed of monoterpenes and flavonoids, with quercetin (8.2%) identified as a significant bioactive component. In preclinical studies using Triton WR-1339-induced hyperlipidemic rat models, the extract has demonstrated potent lipid-modulating properties. Specifically, it has been shown to significantly reduce total cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) while markedly increasing high-density lipoprotein cholesterol (HDL-C). Its therapeutic potential is attributed to the synergistic effects of its constituent flavonoids and monoterpenes on lipid metabolism and antioxidant pathways, although the precise molecular targets require further validation.

Other names
Ruta chalepensis acetone extract

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