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RVG-EVs + Echi
- Development stage
- Preclinical
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
RVG-EVs + Echi (also known as RVG-EVs@Echi) is an engineered nanotherapeutic system designed for brain-targeted delivery in the treatment of Parkinson's disease. It consists of extracellular vesicles (EVs) functionalized with a rabies virus glycoprotein (RVG)-derived peptide, which facilitates crossing the blood-brain barrier (BBB) and selective accumulation in dopaminergic neurons and microglia. The vesicles are loaded with echinatin (Echi), a small molecule NLRP3 inflammasome inhibitor isolated from Glycyrrhiza species. The therapeutic mechanism involves restoring dopaminergic neuron survival through IGF-2–mediated activation of the PI3K/Akt/Nrf2 pathway, reducing neuroinflammation and oxidative stress, and improving motor function in preclinical models.
- Other names
- RVG-targeted extracellular vesicles loaded with echinatin
02
Targets
INSR (Insulin receptor)IGF-1R (Insulin-like growth factor 1 receptor)IGF2 (Insulin-like growth factor 2)Nicotinic Acetylcholine ReceptorNLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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