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RVG-EVs + Echi

Development stage: Preclinical
Modality: Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Intravenous

Overview

RVG-EVs + Echi (also known as RVG-EVs@Echi) is an engineered nanotherapeutic system designed for brain-targeted delivery in the treatment of Parkinson's disease. It consists of extracellular vesicles (EVs) functionalized with a rabies virus glycoprotein (RVG)-derived peptide, which facilitates crossing the blood-brain barrier (BBB) and selective accumulation in dopaminergic neurons and microglia. The vesicles are loaded with echinatin (Echi), a small molecule NLRP3 inflammasome inhibitor isolated from Glycyrrhiza species. The therapeutic mechanism involves restoring dopaminergic neuron survival through IGF-2–mediated activation of the PI3K/Akt/Nrf2 pathway, reducing neuroinflammation and oxidative stress, and improving motor function in preclinical models.

Other names: RVG-targeted extracellular vesicles loaded with echinatin

Targets

IGF-1R (Insulin-like growth factor 1 receptor)Nicotinic Acetylcholine ReceptorINSR (Insulin receptor)IGF2 (Insulin-like growth factor 2)

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