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rVSV∆G-MARV-GP
- Development stage
- Unknown
- Lead developer
- International AIDS Vaccine Initiative
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
rVSV∆G-MARV-GP is an investigational recombinant viral vector vaccine being developed by the International AIDS Vaccine Initiative (IAVI) for the prevention of Marburg virus disease (MVD). The vaccine utilizes a recombinant vesicular stomatitis virus (rVSV) platform, which is the same technology used in the approved Ebola vaccine ERVEBO. It is engineered to express the Marburg virus glycoprotein (GP), the primary target for neutralizing antibodies, to induce a protective immune response. Originally licensed from the Public Health Agency of Canada, the vaccine has shown 100% efficacy in nonclinical lethal challenge models and entered Phase 1 clinical testing in 2026 to evaluate its safety and immunogenicity in humans.
- Other names
- rVSV-MARV-GPMarburg virus vaccine (rVSV-GP)IAVI C104
02
Targets
PYG (Glycogen phosphorylase)
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