S-(2-boronoethyl)-L-cysteine hydrochloride

**S-(2-boronoethyl)-L-cysteine hydrochloride (BEC hydrochloride)** is a boronic acid-based arginine analog and a potent, slow-binding, competitive inhibitor of **arginase I and arginase II**. Its mechanism involves binding to the active site of arginase enzymes, thereby preventing arginine hydrolysis. Reported **Ki** values are 0.4–0.6 μM against recombinant rat arginase I and 0.31 μM (pH 7.5) for human arginase II. BEC hydrochloride is used in biochemical research to investigate the role of arginase in nitric oxide production, endothelial function, inflammation, and cell proliferation, particularly in models of smooth muscle relaxation, pulmonary hypertension, and vascular inflammation. It does not act on inducible nitric oxide synthase at relevant concentrations[2][3][5][6][7].

Other names

(S)-(2-boronoethyl)-L-cysteineHCl(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochlorideMethsuximide Impurity 1