s-(4-nitrobenzyl)glutathione

S-(4-nitrobenzyl)glutathione is a synthetic S-substituted glutathione derivative in which the thiol hydrogen of glutathione is replaced by a 4-nitrobenzyl group. It belongs to the class of oligopeptides and organic sulfides. This compound is primarily used as an experimental tool in biochemical research, notably as a competitive inhibitor of glutathionase (gamma-glutamyl transpeptidase). It serves as a model substrate or ligand for studying glutathione transferases (GSTs), including their structure, function, and ligand-binding properties[1][2][5][7]. There are no approved therapeutic indications or clinical uses for this molecule.

Other names

s-(p-nitrobenzyl)glutathioneS-(4-Nitrobenzyl)glutathione6803-19-6L-γ-glutamyl-S-(4-nitrobenzyl)-L-cysteinylglycine