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S-(D-Carboxybutyl)-L-homocysteine
- Development stage
- Unknown
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
01
Overview
S-(D-Carboxybutyl)-L-homocysteine is a synthetic small molecule and an analog of homocysteine, classified as an alpha amino acid. It acts as a bisubstrate analog inhibitor of betaine-homocysteine S-methyltransferase (BHMT), an enzyme involved in the methylation of homocysteine to methionine using betaine as a methyl donor. By mimicking both substrates, this compound binds to BHMT and induces conformational changes that can protect the enzyme from oxidative inactivation or serve as a tool for studying enzyme mechanism and structure. It is primarily used experimentally in biochemical research rather than clinical settings[1][2][6].
- Other names
- S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE5-{[(3S)-3-amino-3-carboxypropyl]sulfanyl}pentanoic acid5-(((3S)-3-amino-3-carboxypropyl)sulfanyl)pentanoic acid
02
Targets
BHMT (Betaine-homocysteine S-methyltransferase)
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