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S-120083 (also known as V120083) is an orally administered small molecule analgesic and anti-inflammatory agent developed by Shionogi and Purdue Pharma for the treatment of moderate to severe chronic pain, particularly due to osteoarthritis of the knee and other inflammatory pain conditions. The precise mechanism of action remains undefined. It has reached Phase 2 clinical trials in the United States and Japan for indications including chronic pain and knee osteoarthritis.
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