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S-488410
- Development stage
- Phase 2
- Lead developer
- Shionogi
- Modality
- Vaccines & Immunotherapeutics, Peptides
- Administration
- Subcutaneous
01
Overview
S-488410 is an investigational, HLA-A*2402-restricted therapeutic multipeptide cancer vaccine developed from three tumor-associated cancer-testis antigens: URLC10, CDCA1, and KIF20A. The fixed peptide cocktail is intended to prime antigen-specific cytotoxic T-lymphocyte responses against tumor cells that express these antigens. It was studied by subcutaneous administration in patients with advanced non-small cell lung cancer and in advanced or recurrent esophageal squamous cell carcinoma. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01592617))
- Other names
- HLA-A*2402-restricted multipeptide vaccine S-488410S 488410S488410S-488410
02
Targets
HLA-A*24 (Major histocompatibility complex class I molecule presenting MAGE-A4 peptide)T-cell receptor (TCR) recognizing S-488410 peptide–HLA-A*24:02 complexesKIF20A (Kinesin family member 20A)LY6K (Lymphocyte antigen 6 complex locus protein K)NDC80 (NDC80 kinetochore complex component)
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