s-fluoxetine

S-fluoxetine is the S-enantiomer of fluoxetine, a selective serotonin reuptake inhibitor (SSRI) best known as the active component in the antidepressant fluoxetine hydrochloride. It binds to and inhibits the serotonin transporter, blocking serotonin reuptake and increasing its concentration in the synaptic cleft, with downstream effects on mood and anxiety. As a chiral molecule, S-fluoxetine may be assessed separately for pharmacodynamic or pharmacokinetic properties. Like fluoxetine, it may interact with other targets at supratherapeutic doses, including possible positive modulation of the GABA~A~ receptor, antagonism of acid sphingomyelinase, agonism of the sigma-1 receptor, and inhibition of certain ion channels, though its use is primarily research or specialty chemical. The S-enantiomer may be distinguished from R-fluoxetine in investigational or preclinical work, but is not a marketed pharmaceutical entity.

Brand names

S-fluoxetine hydrochloride - Bio-X trade mark

Other names

S-(+)-fluoxetine hydrochloride(+)-fluoxetine hydrochloride(3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride(3S)-N-methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride(gammaS)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine Hydrochloride(S)-Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine HydrochlorideFluoxetine hydrochloride, (S)-methyl-[(3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]azanium;chloride