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s-methylcysteine
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
S-methylcysteine (SMC) is a naturally occurring sulfur-containing amino acid derivative found in various plants, particularly in the *Allium* genus (such as garlic and onions) and certain legumes. It is recognized for its potent antioxidant and anti-inflammatory properties. Research indicates that SMC exerts neuroprotective effects in models of Parkinson's and Alzheimer's disease, primarily through the activation of the Nrf2/HO-1 signaling pathway and the modulation of long non-coding RNAs (lncRNAs) associated with oxidative stress. Additionally, SMC has been investigated for its potential to mitigate reproductive toxicity induced by *Toxoplasma gondii* and serves as a dietary biomarker for the intake of cruciferous vegetables and legumes. It is highly bioavailable when administered orally and is metabolized into various sulfur-containing compounds.
- Other names
- S-methylcysteineSMCS-methyl-L-cysteineL-S-methylcysteine
02
Targets
HMOX1 (Heme oxygenase 1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)
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