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s-methylone
- Development stage
- Unknown
- Lead developer
- Tactogen
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
s-methylone is the (S)-enantiomer of methylone, a synthetic cathinone and structural analog of MDMA. Developed by Tactogen, it is being investigated as a next-generation empathogen for the treatment of post-traumatic stress disorder (PTSD). Mechanistically, it acts as a monoamine releasing agent and reuptake inhibitor, increasing the synaptic concentrations of serotonin, norepinephrine, and dopamine. By utilizing the (S)-enantiomer specifically, the developer aims to optimize the therapeutic window, potentially offering a shorter duration of action and a more favorable side-effect profile compared to racemic MDMA or methylone. It is intended for use in conjunction with psychotherapy to facilitate emotional processing and prosocial effects.
- Other names
- (S)-methylone(S)-bk-MDMA(S)-3,4-methylenedioxy-N-methylcathinone(S)-2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one
02
Targets
NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)HTR2B (5-Hydroxytryptamine Receptor 2B)SERT (Sodium-dependent serotonin transporter)
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