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Drug intelligence / Profile preview
s-pantoprazole
- Development stage
- Phase 3
- Modality
- Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
S-pantoprazole is the S-enantiomer of pantoprazole, a proton pump inhibitor (PPI) that suppresses gastric acid secretion by irreversibly inhibiting the H+,K+-ATPase enzyme system at the secretory surface of gastric parietal cells. This action blocks both basal and stimulated acid secretion. Pantoprazole and its enantiomers are primarily used for conditions involving excessive stomach acid production, such as gastroesophageal reflux disease (GERD), erosive esophagitis, Zollinger-Ellison syndrome, and peptic ulcer disease[1][2][5]. The S-enantiomer may have pharmacokinetic or metabolic differences compared to racemic or R-forms but is not widely marketed under a unique brand name in major markets.
- Brand names
- levopantoprazole
- Other names
- S-enantiomer of pantoprazoledexlansoprazole (not the same but related as an enantiomer)pantoprazole S-enantiomer
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)
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