s16020-2

S16020-2 is a **small molecule olivacine derivative** with potent antitumor activity, developed as a **DNA intercalator and topoisomerase II inhibitor**. It displays high cytotoxicity in vitro and has shown remarkable activity against various solid tumor models in preclinical studies. S16020-2 intercalates into DNA, causing unwinding of the double helix, and selectively stimulates topoisomerase II-mediated DNA cleavage without inhibiting religation, a mechanism distinct from doxorubicin. It has entered phase I clinical trials for cancer indications, with activity and potency exceeding similar compounds in its class[1][2][4].

Other names

178169-99-8S-16020 dihydrochlorideS16020 dihydrochlorideS 16020 dihydrochlorideV5OUA69EM7V-5OUA69EM7V 5OUA69EM79-hydroxy-5,6-dimethyl-1-(N-(2-(dimethylamino)ethyl)carbamoyl)-6H-pyrido(4,3-b)carbazole dichlorohydrate