S1PR1 siRNA

S1PR1 siRNA is a **small interfering RNA** specifically designed to bind and degrade the messenger RNA of **Sphingosine-1-phosphate receptor 1 (S1PR1/EDG1)**, effectively silencing the expression of this G-protein-coupled receptor. S1PR1 is involved in the regulation of immune cell trafficking, vascular growth, and neuronal excitability. Knocking down S1PR1 with siRNA has been shown to reduce S1PR1 protein expression, suppress inflammatory responses, and inhibit processes such as angiogenesis, tumor growth, neuroinflammation, and nociceptive pain signaling[2][3][4]. Experimental use of S1PR1 siRNA demonstrates its ability to modulate disease states by preventing S1PR1-mediated cellular activation and subsequent pro-inflammatory and pro-nociceptive effects[2][3][4]. S1PR1 siRNA is primarily used as a research tool, notably in preclinical studies of pain, inflammation, neurobiology, vascular biology, and cancer.

Brand names

S1PR1 siRNAS-1PR1 siRNAS 1PR1 siRNA

Other names

S1PR1-targeting small interfering RNAS-1PR1-targeting small interfering RNAS 1PR1-targeting small interfering RNAsiRNA against S1P receptor 1