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S31-201
- Development stage
- Preclinical
- Lead developer
- City of Hope Comprehensive Cancer Center
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Intratumoral
01
Overview
S31-201 (also known as NSC 74859) is a cell-permeable small molecule inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3) protein. It specifically targets the STAT3 SH2 domain, thereby preventing STAT3 phosphorylation, dimerization, and DNA-binding activity. By inhibiting the STAT3 signaling pathway, S31-201 induces apoptosis and suppresses the growth of various cancer cells, including activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) and breast cancer. It has been used extensively as a chemical probe in preclinical research to validate STAT3 as a therapeutic target.
- Other names
- NSC 74859NSC74859NSC-74859
02
Targets
STAT5A (STAT5)STAT3 (Signal Transducer and Activator of Transcription 3)STAT1 (Signal transducer and activator of transcription protein 1)
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