Drug intelligence / Profile preview

sabal serrulata + n-acetylcysteine + turmeric extract + chasteberry extract + vitamin b5 + black pepper extract

Development stage
Preclinical
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a **combination dietary supplement** containing the following ingredients: - **Sabal serrulata** (Saw palmetto): used for supporting prostate health, urinary tract symptoms, potential hormone modulation, and possible benefit in male and female reproductive conditions. The mechanism involves partial inhibition of 5-alpha reductase, decreasing dihydrotestosterone (DHT) formation and androgenic stimulation, as well as possible anti-inflammatory activity[1][3]. - **N-acetylcysteine**: an antioxidant and mucolytic agent, also used in liver support and as a precursor for glutathione synthesis. - **Turmeric extract**: often standardized to curcumin, with anti-inflammatory, antioxidant, and potential metabolic benefits. - **Chasteberry extract**: used in gynecology, especially premenstrual syndrome and other menstrual-related complaints, with proposed dopaminergic and prolactin-modulating effects. - **Vitamin B5** (pantothenic acid): an essential B vitamin involved in coenzyme A synthesis; supports metabolism and adrenal function. - **Black pepper extract** (piperine): primarily serves as a bioenhancer by inhibiting metabolic enzymes (notably CYP3A4), increasing the bioavailability of other compounds, and may have mild MAO-B inhibitory effects[2][4]. This blend is typically marketed for *prostate support, hormonal balance, antioxidant support, and enhanced nutrient absorption*, but regulatory approval for any disease indication is lacking. No established brand name or unique manufacturer is widely recognized for this precise formulation.

02

Targets

SRD5A (Steroid 5-alpha-reductase)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)AR (Adrenergic receptors)COXDRD (Dopamine receptors)GSH (Glutathione synthesis / redox)MAOB (Monoamine oxidase B)

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