sabiporide

**Sabiporide** is a potent and selective small molecule inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE1), a transmembrane protein that regulates intracellular pH by exchanging extracellular sodium for intracellular hydrogen ions during acidosis. Developed as a cardioprotective agent, it attenuates ischemia-reperfusion injury, reduces ventricular arrhythmias, myocardial infarct size, and multiorgan damage in preclinical models of myocardial ischemia, hemorrhagic shock, cardiac arrest, and acute metabolic acidosis induced by hypovolemia and lactic acid infusion. Sabiporide improves cardiovascular function by enhancing cardiac output, reducing pulmonary artery pressure and vascular resistance, improving oxygen delivery and tissue perfusion, suppressing proinflammatory cytokines (TNF-α, IL-6), and inhibiting pathways like ERK1/2 phosphorylation and iNOS expression, ultimately lowering mortality without directly correcting acidemia.[1][4][5][6][7][8]

Other names

sabiporide mesilate