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sActRIIB
- Development stage
- Preclinical
- Lead developer
- Merck
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intraperitoneal
01
Overview
sActRIIB is a recombinant protein, often engineered as an Fc-fusion protein, that functions as a ligand trap for the Activin Receptor Type IIB (ActRIIB). It binds to and sequesters multiple ligands, including myostatin (MSTN), activin A, and growth/differentiation factor 11 (GDF11), thereby inhibiting their signaling through ActRIIB. This inhibition promotes skeletal muscle growth (hypertrophy) and can lead to a reduction in fat mass.
- Other names
- soluble activin type IIB receptorsoluble ActRIIB
02
Targets
GDF8 (Myostatin)BMP9 (Bone morphogenetic protein 9)Activin AGDF11 (Growth differentiation factor 11)INHBB (Activin B)
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