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Saffron total-glycoside is a standardized pharmaceutical preparation derived from the stigmas of Crocus sativus L., with crocin as its principal active component. It is formulated as a tablet and primarily investigated for its cardioprotective effects in patients undergoing anthracycline-based chemotherapy for breast cancer. The main mechanism of action is attributed to crocin’s antioxidant and anti-inflammatory properties, which help reduce oxidative stress and prevent myocardial injury induced by chemotherapeutic agents. Saffron total-glycoside has also demonstrated potential benefits in improving cardiac biomarkers (such as troponin I and NT-proBNP) and reducing arrhythmic events during chemotherapy[1][3][4]. Clinical trials are ongoing to establish its efficacy in preventing systolic dysfunction associated with anthracycline cardiotoxicity[1][3][4].
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