SAG602

SAG602 is a cyclic peptide developed for tumor-targeted imaging, specifically designed to bind with high affinity (approximately 10 nM) to the C-terminal domain of MUC1 (MUC1-C), a protein overexpressed in many epithelial cancers. The compound demonstrates high thermal stability, rapid clearance from healthy tissues, and strong selectivity for MUC1-C-positive cancer cells. In preclinical models, SAG602 achieves excellent tumor-to-background ratios and shows promise as an intraoperative imaging agent for fluorescence-guided surgery of malignant lesions expressing MUC1-C. Its safety profile has been favorable in animal studies[6].