Drug intelligence / Profile preview

Sahastara

Development stage
Phase 2
Lead developer
Thammasat University
Administration
Oral
01

Overview

Sahastara (SHT) is a Thai traditional polyherbal remedy included in the Thai National List of Essential Medicine, primarily used for the treatment of knee osteoarthritis. It is typically administered as an ethanolic extract or powdered capsule. Clinical evidence from Phase II trials indicates that Sahastara provides pain relief and functional improvement (measured by VAS and WOMAC scores) comparable to the NSAID diclofenac, but with a significantly lower risk of systemic side effects, particularly regarding liver enzyme elevations (AST, ALT, ALP) and blood pressure changes.

Brand names
Sahastara
Other names
Sahastara remedySHT remedySahastara remedy extract
02

Targets

TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)ABCB1 (P-glycoprotein)CYP3A4 (Cytochrome P450 3A4)ALOX5 (Arachidonate 5-lipoxygenase)

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