Drug intelligence / Profile preview

salicornia herbacea

Development stage
Preclinical
Administration
Oral, Topical
01

Overview

Salicornia herbacea is a **halophytic (salt-tolerant) plant** widely consumed as a vegetable and used in traditional medicine, especially in Asia. Its extracts are rich in **vitamins (A, C, D)**, minerals (zinc, manganese, silica, magnesium, calcium, iron, potassium), polyphenols, flavonoids, carotene, tocopherols, dietary fibers, saponins, sterols, alkaloids, and bioactive compounds such as tungtungmadic acid, quercetin 3-O-glucoside, and isorhamnetin 3-O-glucoside[1][2][3][4][5]. It is traditionally used for a range of health benefits including **anti-oxidative, anti-inflammatory, anti-microbial, anti-proliferative, hypoglycemic, cytotoxic, and immunomodulatory activities**[2][3][1][8]. It is commonly consumed or used for managing **diabetes, obesity, hyperlipidemia, hepatitis, bronchitis, diarrhea, constipation, nephropathy, vision problems, and kidney disease**[2][7][1][3]. Salicornia herbacea is also used as a **salt substitute** with protective effects on blood pressure, the liver, and kidneys[1][5]. Skin care products employ Salicornia herbacea extract for hydrating and barrier-protective purposes[4]. Mechanistic studies suggest it **inhibits inflammatory mediators (e.g., nitric oxide), modulates adipogenesis and osteogenesis, and protects against oxidative stress**[3][2]. No major drug developer or pharmaceutical manufacturer is associated with its development as a pharmaceutical drug.

Other names
Salicorniaglasswortsea asparagussamphire
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)ESR1 (ERα)HMGB1 (High mobility group protein B1)NF-κBNOS2 (Nitric Oxide Synthase 2)

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