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Salicylamide O-acetic acid
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Salicylamide O-acetic acid is a small molecule derived from salicylic acid, characterized by a salicylamide moiety linked to an acetic acid group. It is primarily studied as a salicylate with anti-inflammatory and analgesic properties. The compound has been investigated for use in combination with local anesthetics and corticosteroids for the short-term treatment of inflammation[1][5]. Mechanistically, it is believed to act by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin biosynthesis—key mediators of pain and inflammation[5][6]. Additionally, Salicylamide O-acetic acid can enhance the solubility of other drugs such as theophylline through complex formation, potentially improving their bioavailability[5][6]. Research also suggests modulation of cellular processes via pathways like nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)[5].
- Other names
- 2-(2-carbamoylphenoxy)acetic acid
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)
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